Melatonin's modest benefits and safety concerns prompt calls for more regulation and evidence-based alternatives

While widely used for sleep issues, melatonin’s effectiveness and long-term safety remain uncertain, leading experts to emphasise caution and the importance of evidence-backed options like creatine for strength enhancement.

Melatonin can help some people sleep, but the benefit is usually modest. The hormone helps regulate the sleep-wake cycle, and the Mayo Clinic says it is commonly used for insomnia and jet lag. It also notes that the evidence is strongest for short-term use, while the long-term picture is less certain.

That caution matters because even a widely used supplement is not automatically consistent from bottle to bottle. The Mayo Clinic warns that melatonin may cause headaches, dizziness, nausea and daytime drowsiness, and it advises checking with a clinician before starting it, particularly if you take other medicines or have an autoimmune condition. Reviews from Healthline and the Sleep Foundation add that long-term safety has not been studied as well as short-term use, and that some people report it becoming less effective over time.

Quality is another issue. The column warns that over-the-counter melatonin products can vary sharply in actual dose, and the Mayo Clinic likewise urges caution because supplements are not regulated like prescription drugs. For people who want a more controlled option, ramelteon works on the same melatonin receptor, but it is a prescription medicine and costs far more.

For older adults trying to regain strength, the bigger lesson is to favour evidence over hype. The column argues that extra dietary protein can help muscle building, but that expensive blends with chromium and hydroxymethylbutyrate are not well supported. By contrast, creatine has stronger evidence behind it for improving strength and functional performance when paired with exercise.

Disclaimer: This content is for informational purposes only and is not intended to be a substitute for professional medical judgment, advice, diagnosis, or treatment.